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Research interests
Intracellular transport
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Inside cells, molecular motors attached to microtubules
transport various loads (the cargos) from one to another
location. In many cases, different species of motors
move in opposite directions on the same microtubules.
They can detach from one microtubule and connect to another
one.
We want to understand how these motors organize themselves
in order to have efficient transport.
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In the PHd thesis (2008-2011) of Max Ebbinghaus,
which was a joint thesis between the University of Saarland (with L. Santen),
and the University Paris-Sud, we have shown
that the dynamics of the underlying network
could produce a transition between a jammed
state (static lattice) and an efficient
regime in which the network dynamics
prevents jam formation.
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In her PHd thesis (2013-2015)
which was a joint thesis between the University of Saarland (with L. Santen),
and the University Paris-Sud,
Sarah Klein studied the intracellular transport of
cargos by multiple teams of motors. Some non trivial
effects in the displacement of the cargo
were predicted. Indeed, while common sense would predict
a slowing down of the cargo when the viscosity
of the surrounding medium increases, this is actually
not the case due to the asymmetry between the teams.
An increase of viscosity can speed up the cargo
or even reverse its direction of motion.
A similar effect was predicted when ATP concentration
is varied.
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In another collaboration with I. Weber, L. Santen
and G. Schehr, we are studying the fluctuations
of microtubules under the forces exerted by
molecular motors.
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